Strong Pain-relieving & Fever-reducing Drug Raw Phenacetin Powder White Powder

Strong Pain-relieving & Fever-reducing Drug Raw Phenacetin Powder White Powder

Überlegenheit

Yuanhang Bio-pharmaceutical Technology Co.,Ltd achieves millions of US dollars of salesrevenue in recent years. And there are currently over 400 employers, researchers accounting for 37%. We conducted more than 50 kinds of scientific research, and enjoy more than 20 national patents. We have even acquired national invention patent certificate. 5, 184 products of us are almost unique around the world. Our company’s various raw chemical materials are of reliable quality, most of which conform to the requirements of FCC, USP and BP, it is mainly sold to pharmacy companies and health care companies abroad. Our target markets comprise of USA, Kanada, Vereinigtes Königreich, Brasilien, Niederlande, Irland, Neuseeland, Österreich, Australia and so on.

Produktname: Phenacetin
Synonyme: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4′-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
FALL: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Produktkategorien: Andere APIs;Organics;Amine;Aromaten;Zwischenprodukte & Feinchemikalien;Arzneimittel
Mol-Datei: 62-44-2.mol
Phenacetin Structure

Phenacetin Chemical Properties
Schmelzpunkt 133-136 ° C.(zündete.)
Siedepunkt 132 ° C. / 4mmHg
Fp 2℃
Lagertemperatur. 2-8° C.
form powder
color White
Wasserlöslichkeit 0.076 g/100 mL
Sensitive Hygroscopic
Merk 14,7204
BRN 1869238
Stabilität: Stabil. Unverträglich mit starken Oxidationsmitteln, strong acids.
InChIKey CPJSUEIXXCENMM-UHFFFAOYSA-N
CAS DataBase Reference 62-44-2(CAS DataBase Reference)
NIST Chemistry Reference Acetamide, N-(4-ethoxyphenyl)-(62-44-2)
EPA Substance Registry System Acetamide, N-(4-ethoxyphenyl)-(62-44-2)

Sicherheitsinformation

Hazard Codes T,F
Risk Statements 45-22-20/21/22-36-11
Sicherheitshinweise 53-45-36/37-26-16
RIDADR UN 3077 9 / PGIII
WGK Deutschland 3
RTECS AM4375000
TSCA Yes
Hazardous Substances Data 62-44-2(Hazardous Substances Data)
MSDS Information
Provider Language
4-Acetophenetidine English
ACROS English
SigmaAldrich English
ALFA English

Phenacetin Usage And Synthesis

Indications and Usage Phenacetin is mainly used as an antipyretic analgesic, with slow and lasting effects, treating headaches, Neuralgie, Gelenkschmerzen, and fever, and weakly resisting rheumatism and inflammation. Because of toxic side effects and the rapid development of similar drugs, jedoch, it is no longer used alone, only as a raw material in combination with other drugs. Commonly combined with aspirin and caffeine to form a less toxic compound aspirin used to treat the common cold. Can make chlorpheniramine cold tablets by adding a small amount of chlorpheniramine to the above compound, used to treat colds with headache, Neuralgie, rheumatism, etc. Can be used as a material for organic synthesis or a pharmaceutical intermediate.

Mechanisms of Action On its own, phenacetin has no antipyretic or analgesic effects. In vivo, acetaminophen and paracetamol are metabolized and decomposed to create the antipyretic and analgesic effects. Its decomposites with ammonia and phenyl either not only have no antipyretic and analgesic effects, but also are major factors in its side effects.
Side Effects Long term use may cause renal papillary necrosis and interstitial nephritis, and even induce renal pelvic cancer and bladder cancer. Phenacetin also makes the hemoglobin to form methemoglobin, decreasing blood oxygen carrying capacity, causing cyanosis. In Ergänzung, Phenacetin can cause hemolysis and hemolytic anemia, and is toxic to the retina. Long term use may cause also lead to dependence. Countries including America, Britain, German, and Japan have banned Phenacetin, or required packaging to note that it is “not indicated for long-term usage or large doses.”
Category Toxic Substance

Acute toxicity Oral administration – rats: LD50: 3600 mg/kg; oral administration – mice LD50: 866 mg/kg
Inflammability and Hazardous Property Combustible on open flame; decomposes and releases toxic nitrous oxide gas when heated; side effects: pale color, Leberschäden, hemoglobin disease.
Storage Characteristics Store in ventilated, cool, and dry conditions, separate from reducing agents and food additives.Extinguishing agent Mist, foam, carbon dioxide, sand.Chemical Properties white crystalline powderUses Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.
Uses glycosylation inhibitorDefinition ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.General Description Odorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.Air & Water Reactions Insoluble in water.Reactivity Profile Phenacetin react with oxidizing agents, iodine and nitrating agents.Fire Hazard Flash point data for Phenacetin are not available but Phenacetin is probably combustible.

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