Pharmaceutical Intermediates Pain Killers Paracetamol/ Acetaminophen/ Panadol 103-90-2
Paracetamol is well absorbed in the gastrointestinal tract. Oral bioavailability is dose dependant: with larger doses, the hepatic first pass effect is reduced due to overwhelming of the liver enzymatic capacity; and therefore, bioavailability is increased. Rectal administration of paracetamol is also feasible. In this case, bioavailability is inconsistent and in overall reduced, due to incomplete dissolution of the suppository in the rectum. The absorption rate through this route of administration is elongated.
Paracetamol is distributed throughout the body fluids in a homogeneous way. The analgesic activity is attributable to the small fraction that penetrates into the brain. Paracetamol given at therapeutic doses binds to plasma proteins at less than 20%. In case of intoxication, this proportion may increase to up to 50%.
Paracetamol is essentially metabolized in the liver by conjugation with glucuronic acid (55%) and sulfuric acid (35%). Hepatotoxic metabolites are produced in small amounts by the cytochrome P450 (isoenzyme CYP2E1). In the therapeutic plasma concentration range, this metabolite is detoxified by conjugation with glutathione. In case of intoxication the amount of this toxic metabolite increases and outweighs the amount of available glutathion, which can lead to hepatic failure and renal tubular necrosis.
Paracetamol/ Acetaminophen/ Panadol Verwendung:
Antipyretic analgesics, international non proprietary drug called Paracetamol. It is the most commonly used non anti-inflammatory antipyretic analgesic, antipyretic effect similar to aspirin, the analgesic effect is weak, no anti rheumatic effects of anti inflammation,
Particularly suitable for carboxylic acid can not be used drugs patients. For the common cold, toothache embolism. Acetaminophen is intermediate in organic synthesis, photographic chemicals.Used as antipyretic, analgesic, anti rheumatic drugs.
| Prüfungen |
Normen |
Ergebnisse |
| Aussehen |
White or almost white ,kristallines Pulver. |
Weiß,kristallines Pulver. |
| Identifizierung |
EIN:IR absorption |
Entspricht |
Entspricht |
| B:UV absorption |
Entspricht |
Entspricht |
| C:TLC |
Entspricht |
Entspricht |
| Schmelzpunkt |
168~172C |
169.0~170.9C |
| Wasser |
Not more than0.5% |
0.08% |
| Verwandte Substanz |
|
2ppm |
|
15 ppm |
|
Not detected |
| any other impurity not more than 0.05% |
0.01% |
| Total of other impurities not more than 0.1% |
0.02% |
| Glührückstand |
Nicht mehr als 0.1% |
0.05% |
| Chloride |
Nicht mehr als 0.014% |
Less than 0.014% |
| Sulfate |
Nicht mehr als 0.02% |
Less than 0.02% |
| Sulfide |
Entspricht |
Entspricht |
| Schwermetalle |
Nicht mehr als 0.001% |
Less than 0.001% |
| Free p-aminophenol |
Nicht mehr als 0.005% |
Less than 0.005% |
|
Nicht mehr als 0.001% |
Less than 0.001% |
| Readily carbonizable substances |
Entspricht |
Entspricht |
| Restlösungsmittel |
|
0.08% |
| Assay(anhydrous basis) |
99.0~101,0 % |
99.6% |
| Fazit: Complies with USP34 / BP2011 |
| Testgegenstände |
Spezifikation |
Testgegenstände |
| Aussehen |
White or off-white powder |
weißes Puder |
| Identifizierung |
UV conform |
Entspricht |
| Organic nitrogenous |
Entspricht |
Entspricht |
| Citrate |
Entspricht |
Entspricht |
| Wasser |
Nicht mehr als 1.0% |
0.35% |
| Heavy water |
Nicht mehr als 0.002% |
Entspricht |
| Related impuries |
Related compound A:Nicht mehr als 2.0% |
0.84% |
| Individual:Nicht mehr als 0.5% |
0.36% |
| (Z)isomer |
Entspricht |
Entspricht |
| Organicvolatile impuritise |
Entspricht |
Entspricht |
| Assay |
Between98.0~102.0% |
99.5% |
Competitive advantage:
1. Fachmann
our company is a professional production leading factory in china in pharmaceutical area of many years. delivery areas of our products:us, uk, canada, australia, brazil, russia, portugal, latvia, switzerland, iceland, ukraine, germany, france, netherlands, belgium, peru, sweden, new zealand, the czech republic, lithuania, ireland, tunisia, mexico, greece, puerto rico, thailand, israel and so on.
2. top quality
high quality guarenteed, once any problem is found, the package would be reshipped for you .
3. privilege
a discount would be given when you make a large order.
4. goods in stock
so we can delivery quickly at the very day when receive the payment.
5. discreet package
the packing suits you best would be choosen to cross customs safely. or if you have your own ideal way, it could be also take into consideration .
6. security shipping
Versand per Express (fedex,ups,dhl,ems), by air.the most professional forwarder would be recommanded for you.
7. after-sale service
warm after-sale service for you 24/7. any of your question would be solved for the first as soon as possible.
Purchase Guide
1. Lead Time: Within 12hours after you payment
2. Lieferzeit: 3-7 working days door to door
3. Verpackung: Very discreet or as your requirement
4. Versand: DHL / TNT / UPS / HKEMS / Fedex / etc.
5. Auftragsnummer, Frachtnummer, Sendungscode: The tracking number will give to you after goods send out at first time also the package pictures.
6. Kundendienst: 24/7 online for you to solve problems.
Guarantes:
| Guality Guaranteed |
All sell steroids with USP/BP/EP Standard and Purity reach 98.57%min |
|
Shipping Time Guaranteed |
We can send out parcel within 12 Stunden nach Zahlungseingang, and shipping way recommand based on your location. |
| Delivery Guaranteed |
We guarantee safety shipping, If the parcel is seized/lost/damaged and you receive seizure letter from authority, we will resend the same product for free immediately. We care your business plan and we will never disappoint you. |
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