Pharmaceutical Fine Chemical Nootropic Raw Materials Powder Vinpocetine CAS 42971-09-5 For Brain Improvement

MF:C22H26N2O2

MW:350.45

EINECS:256-028-0

Synonyme:3EIN,16A-APOVINCAMINIC ACID ETHYL ESTER;(3EIN,16EIN)-EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;CAVINTON;ETHYL APOVINCAMIN-22-OATE;EBURNAMENINE;EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;RGH-4405;VINPOCETIN

Schmelzpunkt:147-153 °C dec.

alpha D20 +114° (c = 1 in pyridine)

Lagertemperatur. Bei RT lagern

Löslichkeit DMSO: 5 mg / ml

form solid

color white

Stabilität:Photosensitive

Beschreibung

Vinpocetine, a derivative of the alkaloid vincamine, is an extract from the seeds of the periwinkle plant. It has a long history of use as a traditional tonic to alleviate weariness, especially the type associated with advanced age, and also as an astringent for excessive menses, bleeding gums, mouth sores, and more.

Throughout the world, vincamine has been used to treat senile dementia with significant success. Studies have found vinpocetine to demonstrate many of the same functions as those of vincamine, but without the side effects. Darüber hinaus, it has been shown to be at least two times (and up to three or four times) more potent than vincamine for improving cerebral circulation, Erinnerung, and other functions in humans. No interactions with pharmaceutical drugs have been reported.

Vinpocetine is a biosynthetic nootropic that acts as both a brain booster and neuroprotectant. It’s known for enhancing cognition, sharpening memory, and even improving mood, and it’s safe, well-tolerated, and free of side effects. Vinpocetine is new to many nootropic users, but for anyone who’s interested in thinking and feeling better it’s definitely worth a second look.

Leistungen

Numerous scientific studies have shown vinpocetine to be of benefit for the prevention and improvement of many different kinds of ailments. It enhances cognitive functions, including those involving long- and short-term memory, and it has also been shown to be valuable in protecting heart, visual, and hearing functions, among other benefits.

In broadest terms, vinpocetine is a powerful memory enhancer. It achieves this principally by facilitating cerebral metabolism and improving blood flow in the brain. It works by causing mild dilation of blood vessels, thereby allowing for increased cerebral blood flow, which results in increased oxygenation and glucose utilization.

This makes vinpocetine an ideal candidate not only for the improvement and prevention of certain disease processes in need of increased blood flow and oxygenation, but also for athletes who want to enhance their performance by increasing brain oxygenation, such as skiers, mountain climbers, and high-altitude hikers.

In addition to more efficient brain circulation, vinpocetine has been found to increase brain-cell energy through its effect on the production of ATP (the cellular energy molecule).

Since many brain disorders have been found to be caused by poor circulation or by neuronal damage due to inadequate oxygen and inadequate amounts of energy, it makes sense to consider vinpocetine in one’s daily cognitive supplement program.

Dosierung

Vinpocetine is taken in the daily dosage range of 15-60mg, divided into three daily doses with meals. The standard low dose is 5mg at each of these three meals, with 20mg at each meal being

Medicinal properties and Application

(1) Vinpocetine is a kind of natural medicine extracted from small vinca flower, and belongs to the indole alkaloids. Can be synthetic now. The mechanism of its pharmacological action is to inhibit the activity of calcium dependency phosphodiesterase, increase the content of CGMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow; Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation;

(2) Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism; Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, increase thedegree of oxygen dissociation in hemoglobin; Increase the resistance capacity for cerebral anoxia and occurring of spasm caused by cerebral ischemia, inhibit the generation of lipid peroxide in the brain.

(3) Oral absorption effectively, reach peak at 1 h, then metabolize into Vinpocetine in the body. The half-life of plasma elimination is about 1 hour. For 4 weeks in a row, no accumulation in the body.

(4) Clinical used in cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, cerebral vasospasm, brain endarteritis caused vertigo, tinnitus, Kopfschmerzen, Schwindel, limb numbness, incontinence and other clinical manifestations, Depression, Angst, sleep disorder and other mental symptoms. Clinical experience has shown that it is effective regardless of the length of the course of the disease, and the symptom is fixed or not.

Verwendung

(1) Cerebrovascular drug. A alkaloid extracted from apocynaceae plant, Vincamine derivatives. Selectively inhibit vascular smooth muscle calcium dependency phosphodiesterase, and increase the content of cGMP, expanse cerebral vascular, which in turn increase cerebral blood flow, improve cerebral circulation, but has little effects on the cardiovascular and blood pressure.

(2) Effectively, good tolerance, less adverse reaction. Used for dizziness, Kopfschmerzen, memory disorders, movement disorder, aphasia, hypertensive encephalopathy, usw.. Can also be used in brain blood circulation obstacle caused by mental or neurological symptoms.

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