High Purity Pharmaceutical Raw Steroid Powder Cyproterone Acetate / CPA CAS 427-51-0 For Treatment Of Acne

High Purity Pharmaceutical Raw Steroid Powder Cyproterone Acetate / CPA CAS 427-51-0 For Treatment Of Acne

Überlegenheit

Zhongshan Latterson Biotechnology Co., GmbH., ist ein umfassendes Pharmaunternehmen, die sich auf biopharmazeutische Technologie spezialisiert haben 7 Jahre. Das Unternehmen befindet sich in der Stadt Zhongshan, Provinz Guangdong , China.
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Abstrakt

Cyproterone is a hormone therapy used to treat prostate cancer. It has the brand name Cyprostat. It is a type of drug called an anti androgen.

If you are having cyproterone acetate with a luteinising hormone blocker, it is to stop what is called a flare reaction. When you first start taking LH blockers you actually make more testosterone for the first few days or weeks, which increases the symptoms of the prostate cancer. This soon settles down, and after a few weeks you stop making testosterone. Cyproterone acetate helps to reduce any cancer symptoms caused by this temporary increase in testosterone.

Cyproterone acetate (abbreviated as CPA), sold alone under the brand name Androcur or withethinylestradiol (EE) as Diane or Diane-35 among others, is an antiandrogen and progestogen that is used in the treatment of androgen-related conditions like acne, Hirsutismus (excessive hair growth), early-onset puberty, and prostate cancer, as a component of hormone therapy for transgender women, and in oral contraceptives. It is formulated and used both alone and in combination with an estrogen and is available for use both by mouth and by injection into muscle.

CPA blocks the effects of androgens like testosterone in the body, which it does by preventing them from interacting with their biological target, the androgen receptor (AR), and by reducing their production by the gonads and hence their concentrations in the body. In Ergänzung, it has progesterone-like effects by activating the progesterone receptor (PR). CPA is well-absorbed, is extensively bound to plasma proteins, and has an elimination half-life of around 40 Std.

Common side effects of non-contraceptive (i.e., high) dosages of CPA in men include gynecomastia (breast development) and feminization in general and in both men and women include hypogonadism (low sex hormonelevels), reversible infertility, sexual dysfunction, mental symptoms like depression, fatigue, andirritability, vitamin B12 deficiency, and elevated liver enzymes. Rare but serious adverse reactions of CPA include blood clots, Leberschäden, and certain types of benign brain tumors (specifically prolactinomas andmeningiomas). CPA can also cause adrenal insufficiency as a withdrawal effect if it is discontinuedabruptly from a high dosage.

Medical Uses

Androgen-dependent conditions
CPA is used in the treatment of prostate cancer, precocious puberty, androgen-dependent skin and hair conditions such as acne, Seborrhö, Hirsutismus (excessive hair growth), und androgenetische Alopezie (Muster Haarausfall), hyperandrogenism (Testosteronpropionat im mittleren Körper, in PCOS), and to reduce sex drive in sex offenders or men withparaphilias or hypersexuality. CPA is also widely used as a component of hormone replacement therapy(HRT) for transgender women. In the U.S., where CPA is not available, other drugs with antiandrogen properties like the diuretic spironolactone and the progestin medroxyprogesterone acetate are used instead to treat androgen-dependent conditions besides prostate cancer.

In the treatment of acne in women, a formulation of low-dose CPA in combination with EE has been found to result in overall improvement in 75 zu 90% of patients, with responses approaching 100% improvement.

Hormonal contraception
The combination of CPA and EE, a formulation sometimes referred to as co-cyprindiol, has been available as a combined oral contraceptive since 1978. This formulation is taken once daily for 21 Tage, followed by a 7-day free interval.[Zitat erforderlich] CPA has also been available in combination with estradiol valerate(brand name Femilar) as a contraceptive in Finland since 1993.

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