Anti Early Pregnancy Anabolic Steroid Hormones Female Contraception Levonorgestr
Überlegenheit
Zhongshan Latterson Biotechnology Co., GmbH., ist ein umfassendes Pharmaunternehmen, die sich auf biopharmazeutische Technologie spezialisiert haben 7 Jahre. Das Unternehmen befindet sich in der Stadt Zhongshan, Provinz Guangdong , China.
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Product Details:
Synonyme: 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one;13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one;13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1;17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one;17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one;17-ethynyl-18-methyl-19-nortestosteron;17-ethynyl-18-methyl-19-nortestosterone;18-methyl-17-alpha-ethynyl-19-nortestosterone
FALL: 797-63-7
Assay: 99%
Formel: C21H28O2
Molekulargewicht: 312.45
EINECS: 212-349-8
Dichte: 1.13 g/cm3
Schmelzpunkt: 206 ° C
Siedepunkt: 459.1 °C bei 760 mmHg
Flammpunkt: 95.4 ° C
Aussehen: Testgegenstände
Anwendung: Progesterone medicine
Lagerung: Stored and protected from light
Verwendung: Progesterone drug, used for irregular menstruation, functional uterine bleeding, endometriosis
Beschreibung:
Levonorgestrel (or l-norgestrel or D-norgestrel) is a second generation progestin (synthetic progestogen) used as an active ingredient in some hormonal contraceptives, including combined oral contraceptive pills, progestogen only pills, emergency contraceptive pills, intrauterine systems, contraceptive implants, and hormone replacement therapy. Es steht auf der Liste der unentbehrlichen Arzneimittel der Weltgesundheitsorganisation, a list of the most important medication needed in a basic health system
Levonorgestrel is used in emergency contraceptive pills(ECPs), both in a combined Yuzpe regimenwhich includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5mg (as a single dose or as two 0.75mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 Std (5 Tage) after intercourse could be effective. Levonorgestrel is a synthetic progestin that binds to progesterone and androgen receptors but not the estrogen receptor. Induces apoptosis in ovarian epithelium cells.
Anwendung:
Oral contraception
At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µ G, and triphasic doses of 50 µ G/75 µ G/125 µ G. At very low daily dose of 30 µ G, levonorgestrel is used in some progestogen only pill formulations.
Emergency contraception
Levonorgestrel is used in emergency contraceptive pills (ECPs), both in a combined Yuzpe regimen which includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5 mg (as a single dose or as two 0.75 Testosteronpropionat im mittleren Körper 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 Std (5 Tage) after intercourse could be effective.
Intrauterine system
Levonorgestrel is the active ingredient in the Mirena & Skyla (Jaydess) intrauterine system.
Contraceptive implants
Levonorgestrel is the active ingredient in Norplant and Jadelle.
Hormone replacement therapy
Levenorgestrel is combined with 17-beta estradiol in the Climara Pro hormonal patch.
Applied in pharmaceutical field, Levonorgestrel can be used as an active ingredient in some hormonal contraceptives, including combined oral contraceptive pills, progestogen only pills, emergency contraceptive pills, intrauterine systems and contraceptive implants; Levonorgestrel is safe, tolerated and effective in emergency contraception in woman; Levonorgestrel also can be used for the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
Oral contraceptives, levonorgestrel, also known as D- norethindrone, left Kanok ketone, is currently the most widely used oral contraceptives, the racemic optically active part of norethindrone, the activity ratio norethindrone strong double dose can be reduced by half, adverse reactions are also reduced accordingly. Rapid oral absorption, 0.5 ~ 1h, reached the peak. t1 / 2 von 10 ~ 24h.Protein binding rate of 93% zu 95%, bioavailability, mainly located in the liver, Niere, ovarian and uterine body’s organs and tissues, and its metabolites, mainly in the form of glucuronide and sulfate salts from the urine and feces in vitro. And ethinyl estradiol combination as a short-acting oral contraceptives. Its dual photo and three photo adverse reactions less, closer to women’s normal hormone secretion type. Women can be used for emergency contraception, namely failure (condom slippage or breakage, coitus out of control, rhythm miscalculation, usw.) in the same room of post-coital contraception measures unprotected intercourse or other contraceptive methods.
Echtheitszertifikat:
Produkte |
Spezifikation |
Ergebnisse |
Beschreibung |
White or practically white crystalline powder |
weißes kristallines Pulver |
Spezifische Drehung |
30°~-35° |
32° |
Melting Range |
232~239°C, and melting range is not more then 4°C |
234~238°C |
identification |
It complies with the test for specific optical rotation and melting point |
Entspricht |
|
Infrared absorption spectrophotometry should be consistent with levonorgestrel CRS |
Entspricht |
Trocknungsverlust |
≤0,5 % |
0.20% |
Glührückstand |
≤0,3 % |
0.07% |
Limit of Ethynyl Group |
7.81%~8.18% |
7.92% |
Verwandte Substanzen |
Einzelne Verunreinigung ≤0,5 % |
einzelne Verunreinigung<0.5% |
|
Total Impurities ≤2.0% |
Total impurities<2.0% |
Organic Volatile impurties |
Ethanol ≤5000ppm |
1200ppm |
Assay |
The product complies with specification in USP34 |
Dosierung:
At low doses, levonorgestrel is used in monophasic and triphasic formulations of combined oral contraceptive pills, with available monophasic doses ranging from 100-250 µ G, and triphasic doses of 50 µ G/75 µ G/125 µ G. At very low daily dose of 30 µ G, levonorgestrel is used in some progestogen only pill formulations.
As the three weekly photo of reducing the product with about 40%, so the fewer adverse reactions. Levonorgestrel such as changes in dosage form can also be used a variety of long-acting contraceptives. Used as a short-acting oral contraceptives: from the first five days of menstruation to start taking the compound levonorgestrel tablets, a day, even for 22 Tage, without interruption, at bedtime. So the next menstruation after serving five days to continue the medication. May have nausea, vomiting, Kopfschmerzen, breast swelling after serving, Akne, Gewichtszunahme, Depression, lowered HDL, breakthrough bleeding, amenorrhea. Leber- und Nierenfunktionsstörung, breast masses were hanged. Uterine fibroids, hypertension and liver and kidney disease history of caution. Not as a regular birth control pills, to be taken next reliable contraceptive measures premenstrual medication. Women who smoke should not take (due to complicated by cardiovascular disease).
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