CAS 298-46-4 Pharmaceutical Grade Raw Materials Carbamazepine White Powder

Superiority

Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
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Product Details:

Carbamazepine
CAS number: 298-46-4
Molecular formula: C15H12N2O
Molecular weight: 236.27
EINECS No. 206-062-7
Standard: Enterprise standard
Natural / synthetic: synthetic
Purity: Medical grade
Content: 99%
Appearance: white powder
Ingredients: Carbamazepine
Physical and chemical properties: white or almost white crystalline powder. 204-206 ° C (190-193 ° C). Soluble in ethanol, acetone, propylene glycol, do not dissolve in water. Odorless, tasteless.
Area: Anticonvulsants
Downstream Products: Carbamazepine Capsules
Use: Anticonvulsants for the treatment of epileptic seizures and psychomotor epilepsy, but also for the treatment of trigeminal neuralgia. Carbazepine is a dibenzazepine antiepileptic drug with similar anticonvulsant effect to phenytoin. It is most effective on episodes of psychomotor attacks and is also effective on major episodes, localized episodes, and mixed episodes. This product is better than phenytoin anti-peripheral nerve pain role, can be used for trigeminal neuralgia and glossopharyngeal neuralgia. Can also be used for treatment of arrhythmia and diabetes insipidus embolism.

Description:

Carbamazepine (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.It is not effective for absence seizures or myoclonic seizures. It is used in schizophrenia along with other medications and as a second line agent in bipolar disorder.Carbamazepine appears to work as well as phenytoin and valproate. Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain;Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy.;Carbamazepine is also used to treat bipolar disorder.

Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is used off-label as a second-line treatment for bipolar disorder and in combination with an antipsychotic in some cases of schizophrenia when treatment with a conventional antipsychotic alone has failed. It is not effective for absence seizures or myoclonic seizures. In the United States, the FDA-approved medical uses are epilepsy (including partial seizures, generalized tonic-clonic seizures and mixed seizures), trigeminal neuralgia, and manic and mixed episodes of bipolar I disorder.

Application:

The mechanism of action of carbamazepine and its derivatives is relatively well understood.[medical citation needed] Carbamazepine is a use-dependant blocker of voltage-gated sodium channels. It is ionised within intracellular fluid, and is then able to bind to activated voltage-gated sodium channels, preventing repetitive and sustained firing of an action potential.This leaves the affected cells less excitable until the drug dissociates. Carbamazepine is also a GABA receptor agonist, as it has also been shown to potentiate GABA receptors made up of alpha1, beta2, and gamma2 subunits.[26] This mechanism may contribute to its efficacy in neuropathic pain and bipolar disorder. Laboratory research has further demonstrated that carbamazepine is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor.

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