CAS 25513-46-6 Cosmetic Raw Materials Gamma – Polyglutamic Acid With Whitening

Superiority
Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
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Product Detals:

CAS Number: 25513-46-6

Chemical Formula: [C5H9NO4]n

Molecular Weight: 300K or 700K Da

Description:

γ-PGA(gamma-PGA), full name: Gamma-poly-glutamic acid, is a natural occurring, multi-functional, and biodegradable biopolymer. It is produced through fermentation by Bacillus Subtilis using glutamic acid. PGA is consists of glutamic acid monomers cross-linked between α-amino and γ-carboxyl groups, and the molecular weight of PGA is usually between 100~1000K Da. It is water-soluble, edible and non-toxic towards human, and is environment friendly. It has broad applications in the fields of medicine, food, cosmetics, water treatment and agriculture.
Polyglutamic acid ( PGA ) is a polymer of the amino acid glutamic acid ( GA ). Gamma PGA ( Poly- γ – glutamic acid, γ – PGA ) – the form where the peptide bonds are between the amino group of GA and the carboxyl group at the end of the GA side chain ) – is a major constituent of the Japanese food natto.
Gamma PGA has a wide number of potential uses ranging from food and medicine to water treatment. It is widely being used as a drug delivery system in cancer treatment and research is underway for its application in a treatment of type I diabetes and its potential use in the production of an AIDS vaccine.

Application:

Effectively Increasing NMF in Inner Skin As a hygroscopic material produced by skin, Natural Moisturizing Factor ( NMF ) provides moisture for skin in cuticle. The NMF including amino acids which are hydrolyzed on skin matrix protein ( e.g. Filament aggregating protein ), pyrrolidone carboxylic acid ( PCA ), lactic acid and urocanic acid ( UCA ) can retain moisture of skin. Gamma PGA is the only effective ingredient that is known till now to induce the production of NMF to 130% of the normal level. Gamma PGA can lock the moisture in inner skin by promoting the growth of fibroblast and increasing the content of NMF in horn cells.

Improving Nutrient Supply
Thanks to its controlled release property, gamma PGA can control the release of nutrients and moisture in a continuous manner. Each gamma PGA monomer has ionized groups likeα COOR, -CO and -NH, which can absorb electropositive nutrients. Hence a good embedding delivery system is created and active ingredients in cosmetics can possibly maximize their efficacy.

Healthy Whitening Efficacy
Gamma PGA can also whiten skin by controlling melanin synthesis to prevent and reduce wrinkle’s. Ultraviolet irradiation is the main incentive of tyrosinase, which in tum induces the formation of Melanin. As gamma PGA, either HM gamma PGA ( 0.5% ) or LM gamma PGA ( 0.5% ) can effectively inhibit the formation of melanin. Meanwhile, gamma PGA can form a film upon surface of skin which fences out ultraviolet.

Applications of Gamma PGA in Skin – care Products
Gamma PGA has excellent compatibility in non-ionic, anionic and amphoteric surfactants. It is a perfect ingredient for cream, essence, astringent, face mask, eye gel, sun cream, shampoo, body wash, lotion, hairstyle formula and so on.

Specification:

Advantages over other commercial available polymers:

Non toxic, Biodegradable and degraded end products are glutamates which are nutritional ingredients to skin.
Fully compatible with all skin conditions and provide long lasting moisturizing effect better than HA ( Hyaluronic acid ) and Collagen.
Is required in very less concentration hence cost effective.
Gamma – PGA derivatives have excellent strength, transparency and elasticity.
Gamma – PGAcan be used in skin care products, shampoo, hair lotion, shaving cream and lipsticks

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