CAS 148553-50-8 High Purity Local Anaesthesia Drugs White Pregabalin/β-isobutyl-GABA for Pain Killer
Superiority
Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.
Description:
Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.
The capsule shells contain gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. The imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide.
Quick Details:
Synonym: Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99.5%
Appearance: White Crystal Powder
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Express: EMS, DHL, FedEx, etc(door-to-door)
Usage: New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment.
COA:
| Items of analysis |
Specification |
Results |
| Appearance |
White or almost white powder |
conforms |
| Identification |
IRandHPLC |
conforms |
| Loss on drying |
≤0.5% |
0.2% |
| Specific Rotation |
+10°~+12° |
+10.77° |
| Residue on ignition |
≤0.1% |
0.08% |
| Heavy metals |
≤20ppm |
conforms |
| impurity C |
≤0.1% |
conforms |
| Any impurity |
≤0.1% |
0.044% |
| Total impurity |
≤1.0% |
0.14% |
| Assay(HPLC) |
98%-101% |
99.6% |
| R-isomer |
≤0.15% |
0.033% |
| Bromide cintent(Titrmetry) |
≤500ppm |
26ppm |
| Ethanol |
≤5000ppm |
conforms |
| Isopropyl alcohol |
≤5000ppm |
142ppm |
|
≤5000ppm |
conforms |
|
≤60ppm |
conforms |
| Conclusion |
Qualified |
Application:
Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. S-Enantiomer of Pregabalin. A GABA analogue used as an anticonvulsant. Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.
Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster). It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep).
Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body. Pregabalin works by reducing the abnormal electrical activity in the brain. It is taken alongside other medicines for epilepsy. Pregabalin can also be helpful in treating the symptoms of generalised anxiety disorder (GAD), particularly if other medicines which are more often prescribed for people with this condition are not suitable. GAD is along-term condition where anxiety is amajor symptom.
Pregabalin, also known as -isobutyl–Aminobutyric acid (-isobutyl-GABA) and sold under the trade name Lyrica among others, is amedication used to in the treatment of epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults. Pregabalin is astructural analogue of the neurotransmitter GABA, consequently it belongs to the -Aminobutyric acid analogue class of antiepileptic drugs. Its aion channel modulator that has analgesic, anticonvulsant, sedative, and anxiolytic properties. Pregabalin is apotent gabapentinoid and close analogue of GABOB (-hydroxy-GABA), baclofen (-(4-chlorophenyl)-GABA), and phenibut(-phenyl-GABA).
Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is prescribed for the treatment of several different conditions. You may have been prescribed it for the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or ‘focal’ symptoms. Pregabalin is also prescribed to treat certain types of long-lasting pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a number of different conditions, including diabetes (where it is called diabetic neuropathy) and shingles(where it is called postherpetic neuralgia).
Usage:
1. Pregabalin works by reducing the abnormal electrical activity in the brain. It is taken alongside other medicines for epilepsy. Pregabalin can also be helpful in treating the symptoms of generalised anxiety disorder (GAD), particularly if other medicines which are more often prescribed for people with this condition are not suitable. GAD is a long-term condition where anxiety is a major symptom.
2. Pregabalin is a medication used to in the treatment of epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.
3. Pregabalin is a structural analogue of the neurotransmitter GABA, consequently it belongs to the acid analogue class of antiepileptic drugs. Its a ion channel modulator that has analgesic, anticonvulsant, sedative, and anxiolytic properties. Pregabalin is a potent gabapentinoid and close analogue of GABOB, baclofen, and phenibut.
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