BP Standard Pain-relieving Drug Phenacetin,Fever-reducing Drug Phenacetin
CAS Number: 62-44-2
purity:99%
Appearance: off-white powder
category:Pharmaceutical grade
Packing: 25kg/drum
Formula: C10H13NO2
Molecular Weight: 179.24
EINECS: 200-533-0
Density: 1.099 g/cm3
Melting Point: 133-136 C(lit. )
Boiling Point: 355.1 C at 760 mmHg
Flash Point: 168.5 C
Solubility: 0.076 g/100 mL in water
Phenacetin is a white crystalline powder with the chemical composition C10H13NO2. It was first developed by Harmon Northrop Morse in 1878. In addition to its pain-reducing properties, it also has been used as a fever-reducer, a treatment for rheumatoid arthritis and a treatment for intercostal neuralgia, a rare disorder that causes pain in the nerves around the ribs. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities.
Phenacetin usage:
1. antipyretic analgesics for the treatment of fever, headache, neuralgia, etc.
2. antipyretic analgesic. Antipyretic and analgesic effects of non phenacetin and “aspirin” similar, mainly used as antipyretic analgesics, action slow and protracted, have better curative effect on the treatment of headache, neuralgia, arthritis pain and fever, but anti rheumatism, anti-inflammatory effect is weak. Excessive dosage can cause High-speed Rail hemoglobin disorders, resulting in hypoxia, long-term use can damage the kidneys, and even cause papillary necrosis, should be used with caution. Due to the rapid development of its toxic side effects and other similar drugs, the drug has been stopped alone, just as raw materials and other drug compound preparation. Often associated with aspirin, caffeine together form a compound aspirin, which is composed of non phenacetin 0.162 grams, 0.227 grams, 0.035 grams of aspirin, caffeine, low toxicity, for the treatment of colds. Such as the addition of the drug in a small amount of chlorpheniramine, also can be made into chlorpheniramine cold tablets, can be used for the treatment of cold headache, neuralgia, rheumatism and so.
3. non phenacetin in itself is not the antipyretic and analgesic effects, in the body, after metabolism decomposition of acetaminophen or paracetamol, just play the antipyretic and analgesic effect. Also the decomposition of ammonia benzene ether, not only without the antipyretic and analgesic effects of ammonia benzene ether, and is a major factor in toxicity of phenacetin non.
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The COA of Phenacetin:
| Product name |
Phenacetin |
| CAS No. |
62-44-2 |
Outer Packing |
25KG |
| Production date |
2016.05.07 |
Shelf life |
2019.05.05 |
| Standard adopted |
BP68 |
| Items of analysis |
Specification |
Results |
|
Description |
Should comply with the standard |
Comforms |
|
Identification |
Positive |
Positive |
|
Melting point |
134℃ to 136.5℃ |
134.5℃ to 136.5℃ |
|
4-chloroacetanilide |
BP1968 |
＜3.5ml/0.6g |
|
P-Phenetidine |
BP1968 |
Comforms |
|
Sulphated ash |
≤0.1%
≤0.1% |
0.07%
0.07% |
|
Assay |
≥99% |
99.1% |
|
through a uss#80 |
|
98% |
| Conclusion |
Qualified |
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