Analgesic Powder Tetracaine HCl Pain Killer Safe Pass
Abstract
| Name |
Tetracaine Hydrochloride, Tetracaine HCl |
| CAS No |
136-47-0 |
| EINECS |
205-248-5 |
| MF |
C15H25ClN2O2 |
| MW |
300.82 |
| Melting point |
149°C |
| Assay |
99% |
| Appearance |
White Crystal Powder |
| Grade |
Pharmaceutical Grade |
| Storage |
Closed, confined and shading preservation |
Description:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine hydrochloride COA
| Items |
QUALITY STANDARDS |
RESULTS |
| Description |
White or almost white crystalline powder |
White crystalline powder |
| Solubility |
Matching with the working standard |
Complies |
| Identification |
A.By IR, To match with working standard |
Complies |
| B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80ºC for 2h,melts at about 131ºC |
Complies |
| C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of acetone R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops |
Complies |
|
D. Solution S gives reaction of chlorides. |
Complies |
| PH |
4.5~6.5 |
5.78 |
| Residual Solvents |
Conform to standard |
Complies |
| Claruty |
Solution should be clear |
Complies |
| Related Substances |
Conform to standard |
Complies |
| Heavy metals |
≤10ppm |
<10ppm |
| Loss on drying |
≤1.0% |
0.87% |
| Resiue on ignition |
≤0.1% |
0.05% |
| Melting range |
148ºC |
147.5ºC~150.8ºC |
| Assay(*) |
99%~101.0% |
100.40% |
| Conclusion |
The Sample Complies With Specification of EP8 |
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