Pharmaceutical Raw Material Allopurinol CAS 315-30-0 Treating acute lymphoblastic leukemia
Quick Details:
Product Name: Allopurinol
Synonyms: TIMTEC-BB SBB004202;ISOPURINOL;LABOTEST-BB LT00244764;HPP;1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL;AKOS BBS-00005290;ALLPURINOL;AKOS BBS-00002073
CAS: 315-30-0
MF: C5H4N4O
EINECS: 206-250-9
Product Categories:PYRIMIDINE;Miscellaneous Natural Products;Heterocyclic Compounds;Antitumors for Research and Experimental Use;Chemical Reagents for Pharmacology Research;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Fused Ring Systems;API’s;Miscellaneous Enzyme;Bases & Related Reagents;Nucleotides;ZYLOPRIM;inhibitor;Other APIs
Mp:>300 °C(lit.)
storage temp. Room temperature.
Water Solubility:0.35 g/L (25 ºC)
Merck :279
CAS DataBase Reference:315-30-0(CAS DataBase Reference)
NIST Chemistry Reference:Allopurinol(315-30-0)
EPA Substance Registry System:4H-Pyrazolo[3,4- d]pyrimidin-4-one, 1,5-dihydro-(315-30-0)
Hazard Codes:T,Xi,Xn
Risk Statements:25-43-36/37/38-20/21/22
Safety Statements:28-36/37-45-36/37/39-26-24-36
RIDADR:UN 2811 6.1/PG 3
WGK Germany:2
RTECS:UR0785000
HazardClass :6.1
Application:
Allopurinol inhibits the breakdown (catabolism) of the thiopurine drug mercaptopurine, and was specifically invented by Gertrude Elion to enhance the action of mercaptopurine in the treatment of acute lymphoblastic leukemia. However, no improvement in leukemia response was noted with mercaptopurine-allopurinol cotherapy, and this use of the drug was abandoned.
Allopurinol is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.
Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as these regimens can rapidly produce severe acute hyperuricemia, although it has gradually been replaced by urate oxidase therapy
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