53179-13-8 Pharmaceutical Active Ingredients Powder Antineoplastic Pirfenidone

Quick detail

Product name: Pirfenidone

Other name: Arm-69

CAS: 53179-13-8

appearance: Off-White Solid

purity: 99%

Trademark: Pharmlab

Original: China

Grade: Pharmaceutical grade

Package: Disguised package ; Foil bag

Delivery date: 3-5 work days

Certificate: ISO 9001, USP,GMP

Payment: Western Union, MoneyGram, T/T, bitcoin

Shipping: EMS,HKEMS,EUB,ETK,FEDEX,DHL,UPS,Aramex,ETC

Policy: Re-Shipping Policy

MF: C12H11NO

MW: 185.22

mp: 96-97°C

storage temp: Store at RT

solubility DMSO: ≥10 mg/mL, soluble

COA

product description

In vitro, pirfenidone can inhibit the proliferation of uterine leiomyoma cells and leiomyoma cells. Pirfenidone inhibits the formation of collagen in TGF-β-1-induced fibroblasts. Inhibition of PDGF, FGF and TGF-β-1 induced fibroblast proliferation. In the hamster model, pirfenidone, orally, prevents and treat bleomycin-induced pulmonary fibrosis. Pirfenidone can prevent chemically induced rat sclerosing peritonitis and can also be treated with keloid transplantation for nude mice.

Pirrenidone 0.01 1 mg / ml can inhibit the matrix and dose-dependent manner of serum stimulation of uterine fibroids and leiomyoma cell DNA synthesis, the compound without cytotoxicity, the collagen mRNA levels have no effect. Pirfenidone in the hamster pulmonary fibrosis model can reduce the level of collagen I mRNA levels before the disease, reduce lung proline levels and malondialdehyde and lung preservation of amino acid hydroxylase activity.

Product Application

Pirfenidone is an antiinflammatory drug used to treat idiopathic pulmonary fibrosis. Anti-fibrosis agents, effective lung and pulmonary fibrosis models. Inhibit collagen production and fibroblast proliferation. Regulate the level of cytokines after oral administration of the body. Free radical scavengers and lipid peroxidation inhibitors. Pirfenidone inhibits collagen production and fibroblast proliferation. Antibacterial and antiinflammatory properties have been shown in various pulmonary fibrosis animal models and in clinical trials.

How to use pirfenidone

Use pirfenidone in accordance with the doctor’s instructions. Check whether the label on the drug has an accurate dose description.Phenylethanone can provide additional patient leaflets. If you have any questions about this information, please contact your pharmacist.Palladium with food orally.If you take pirfenidone at the same time every day, the best effect.If you miss a dose of pirfenidone, put it as soon as possible. If your next dose is almost time, skip the missed dose and return to your regular dosing regimen. Do not take 2 doses at a time.If you miss the 14-day or more days of pirfenidone, call your doctor to understand how to handle it.For questions about how to use pirfenidone, consult your health care provider.

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