Zhongshan Latterson Biotechnology Co., Ltd.

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  • Nootropics Active Pharmaceutical Ingredients Donepezil CAS 120014-06-4 For Brain

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    Other Hot-Sale Products (Raw Powder)
    Model Number : CAS: 62613-82-5
    Certification : GMP,SGS,ISO9001:2008,KOSHER
    Place of Origin : China
    MOQ : 10g
    Price : Negotiable
    Payment Terms : Western Union, MoneyGram, Bank Transfer, Bitcoin
    Supply Ability : 3000KG/Month
    Delivery Time : Usually within 7 work days
    Packaging Details : Stealth and discreet packaging
    Product Name : Oxiracetam
    CAS : 62613-82-5
    MF : C6H10N2O3
    MW : 158.16
    Assay : 99%
    appearance : white Solid
    enquiry
    • Specifications

    Nootropics Active Pharmaceutical Ingredients Donepezil CAS 120014-06-4 For Brain

    Superiority

    Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
    Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.

    Product Details:

    Product name Donepezil
    Synonyms 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;

    1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE;

    AKOS 226-23;2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inde;

    n-1-one;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;

    5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one

    Assay 99%
    CAS No 120014-06-4
    Packing Customized package as you require
    M.F. C24H29NO3
    M.W. 379.49
    EINECS 1312995-182-4
    Melting point 207°C
    Appearance White crystalline powder
    Brand Name Sendi
    Quality Standard Enterprise Standard
    Usage Treatment of depression.

    Description:

    Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer’s disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

    Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer’s patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

    A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

    Application:

    Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.

    Donepezil binds and inactivates reversibly the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses. The precise mechanism of action of donepezil in patients with Alzheimer’s disease is not fully understood. Certainly Alzheimer’s disease involves a substantial loss of the elements of the cholinergic system and it is generally accepted that the symptoms of Alzheimer’s disease are related to this cholinergic deficit, particularly in the cerebral cortex and other areas of the brain. It is noted that the hippocampal formation plays an important role in the processes of control of attention, memory and learning. Just the severity of the loss of cholinergic neurons of the central nervous system (CNS) has been found to correlate with the severity of cognitive impairment.

    COA:

    TEST ITEM SPECIFICATION RESULT
    Appearance Off white to white crystalline powder Complies
    Solubility freely Freely soluble in chloroform, soluble
    in water and Acetic acid, slightly soluble in
    Acetonitrile and ethanol, insoluble in
    Ethylacetoacetate and n-hexane
    Complies
    Identification (1)By IR absorption ,To match with working
    standard
    Complies
    (2) The retention time of the major peak of
    the sample should accord with that of the
    working standard.
    Complies
    (3) Test for chlorides. Reponds to the test
    for Chlorides.
    Complies
    PH 4.0-7.0 6.10
    Residue on ignition ≤0.1% 0.03%
    Related substance Any Unkonwn single impurity≤0.3%
    Total ≤0.5%
    0.04%
    0.18%
    Heavy metal ≤10ppm <10ppm
    Residual Solvents Methanol≤0.3%
    Ethanol≤0.5%
    Ethyl acetate≤0.5%
    Toluene≤0.089%
    Acetic acid≤0.5%
    Not detected
    Not detected
    Not detected
    Not detected
    Not detected
    Loss on drying ≤0.5% 0.20%
    Assay On dried base, C24H29NO3·HCl
    should be 98.0% to 102.0%
    100.20%
    Conclusion: The product complies to Enterprise standard

    Dosage and Administration:

    Allow Donepezil hydrochloride ODT to dissolve on the tongue and follow with water.

    1) For Mild Moderate Alzheimer user:

    Starting dosage: 5 mg administered once per day in the evening, just prior to retiring.

    2) For mild to moderate Alzheimer user:

    The maximum recommended dosage is 10 mg per day.

    A dose of 10 mg should not be administered until patients have been on a daily dose of 5 mg for 4 to 6 weeks.

    Our service

    1.100% reshipment policy is our business basic.100% reshipment immediately if your parcel stays Customs for 4 days and doesn’t get updated.
    2.Total refund for 15 days of dissatisfaction with quality.
    3.We can provide free samples.
    4.We have a special packing ,It can be easily passed through the customs.It will be more safe.
    5.Our company have a long term cooperate with DHL.EMS.Fedex and so on .It can be sent to your hand more quickly. Parcel photo should be offered within 12hours after receiving your steroid payment.
    6.If you have a chance to come to China. I can show you our lab.
    7.Our company has WU, MG, TT, and Bitcoin payment ways in advance.You can pay 95% for the peptides cost at first for order, the rest can offer us in your next order;

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