Introduction
Androstane-diones are a pair of isomeric steroids which differ at the 5-position. They are distinguished as 5α-androstane-dione and 5β-androstane-dione. In humans, 5α-androstane-dione is a metabolic precursor of both testos-terone and estrone.
Usages
Simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroids, norethisterone, testosterone propionate in the middle Body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
Simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroids, norethisterone, testosterone propionate in the middle Body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
4-Androstenedione is further converted to either testosterone or estrogen.
In males, conversion of androstenedione to testosterone requires the enzyme 17β-hydroxysteroid dehydrogenase.
In females, androstenedione is released into the blood by theca cells. Conversion of androstenedione to estrogen (e.g., estrone and estradiol) requires the enzyme aromatase. Androstenedione is a substrate for estrogen production in granulosa cells which produce aromatase. Thus, theca cells and granulosa cells work together to form estrogens.
Used for simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroid, norethisterone, testosterone propionate in the middle body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
Effects
Because androstenedione can be converted to estrogenic steroids, people taking this supplement may have estrogenic side-effects.
4-Androstenedione has been shown to increase serum testosterone levels over an eight-hour period in men when taken as a single oral dose of 300 mg per day, but a dose of 100 mg had no significant effect on serum testosterone. However, serum levels of estradiol increased following both the 100 mg and 300 mg doses. The study also reported that the serum level of estrogens and testosterone produced varied widely between individuals.
In child development, higher levels of androstenedione in boys have been associated with higher levels of acting out behaviors.
Dosing
Dietary supplement dosages of androstenedione range from 5 to over 50mg per day in the morning or 60 minutes before working out. Experts suggest the best way to take andro is by cycling it. The proper cycle is six weeks of taking it followed by two weeks off.
How is 4-androstenedione controlled?
Due to its secretion from a number of different glands and its often rapid conversion to other hormones, the control of 4-androstenedione within the body is very complex. However, two key parts of the brain (thehypothalamus and pituitary gland) are known to be important in the control of 4-androstenedione secretion from the testes, ovaries and adrenal cortex.
The release of 4-androstenedione by the adrenal cortex is thought to be related to the pituitary gland’s secretion of a specialised hormone, adrenocorticotropic hormone. Precisely how adrenocorticotropic hormone and other hormones control the adrenal gland’s production of 4-androstenedione is, however, unclear.
The testes and ovaries are stimulated to release 4-androstenedione by luteinising hormone and follicle stimulating hormone. These are released from the anterior pituitary gland in response to a hormone signal from the hypothalamus.
What happens if I have too much 4-androstenedione?
The effects of too much 4-androstenedione are likely to result from its conversion in the body to oestrogen or testosterone.
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