99% Purity Pharmaceutical Raw Powder Beta-Nicotinamide Mononucleotide / Beta-NMN For Anti Aging 1094-61-7
Quick detail
| Product name |
β-NMN, Beta-Nicotinamide Mononucleotide |
| β-NMN CAS: |
1094-61-7 |
| β-NMN Assay: |
99.5% |
| β-NMN MF: |
C11H15N2O8P |
| β-NMN MW: |
334.22 |
| β-NMN EINECS: |
214-136-5 |
| β-NMN storage |
temp. 2-8°C |
| β-NMN Chemical Properties: |
White powder. |
| β-NMN Payment: |
T/T, Western Union and Money Gram |
| β-NMN Delivery: |
Within 24hours After Your Payment |
| β-NMN Express: |
EMS, DHL, FedEx, etc(door-to-door) |
β-NMN: Description:
Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
Application
The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.
NMNAT1 is the most widely expressed of three orthologous genes with nicotinamide-nucleotide adenylyltransferase (NMNAT) activity. Genetically engineered mice lacking NMNAT1 die during early embryogenesis, indicating a critical role of this gene in organismal viability.[citation needed] In contrast, mice lacking NMNAT2, which is expressed predominantly in neural tissues, complete development but die shortly after birth. However, NMNAT1 is dispensable for cell viability, as homozygous deletion of this gene occurs in glioblastoma tumors and cell lines. NMNAT enzymatic activity is probably essential at the cellular level, as complete ablation of NMNAT activity in model organisms leads to cellular inviability.
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