CAS 638-94-8 Pharmaceutical Raw Materials Desonide For Anti – Inflammatory
Superiority
Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.
Product Details:
Product name: Desonide
English Synonyms: (11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione;16-alpha-hydroxyprednisolone-16,17-acetonide;17-acetonide,16-alpha-hydroxy-prednisolone-1;steroderm
CAS NO.: 638-94-8
EINECS: 211-351-6
Molecular Formula:C24H32O6
Molecular Weight:416.51
Assay: 99%
Appearance: White powder
Usage: With acetal-based adrenal cortex hormones
How to use desonide topical:Use this medication only on the skin.
Description:
Desonide is the generic name of a lowpotency topical corticosteroid that has been available Since the 1970s. It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile And is available as a cream, ointment lotion, and as a foam under the tradename Verdeso Foam.Desonide Ointment, 0.05% contains Desonide (Pregna – 1,4 – diene – 3,20 – dione,11,21 – dihydroxy – 16,17 – [(1 – methylethylidene)bis(oxy)] – ,(11β,16α)) a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primary synthetic steroids used topically as anti-inflammatory and antipruritic agents.
Chemically, Desonide, the active ingredient in Desonide Ointment, 0.05% is C24H32O6. The molecular weight of Desonide is 416.51. It is a white to off-white powder. The solubility of Desonide in distilled water saturated with ether is 184 mg/L. Each gram of Desonide Ointment, 0.05% contains 0.5 milligram of Desonide microdispersed in a base of white petrolatum.
Application:
Desonide belongs to the group of medications known as topical corticosteroids. It is used to Treat various skin conditions, including rashes. It works by reducing inflammation and itching.Endogenous eczema clinical cure rate, the overall curative effect is distinct, and the low Incidence of adverse reactions, is a safe and effective external cortex hormone.
Desonide is a prescription topical treatment for redness, swelling, itching, and discomfort of various skin conditions. Regardless of the vehicle used, desonide is applied 2 to 3 times a day, at the same times each day. Skin conditions typically improve in the first two weeks of treatment. Patients are instructed to use desonide for the minimum amount of time necessary for conditions to improve.
This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis,allergies, rash). Desonide reduces the swelling, itching and redness that can occur in these types of conditions. Desonide is a mild corticosteroid.
Desonide Ointment, 0.05% is a low potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
It should not be used for longer than two weeks unless directed by a physician.
Wash your hands. Before applying the medication, clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 2-3 times daily, or as directed by your doctor. If using the gel, apply the gel usually only 2 times daily. Do not bandage, wrap, or cover the area unless you are instructed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.
After applying the medication, wash and dry your hands, unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes because this may worsen or cause glaucoma, or cause irritation. Also, avoid getting this medication in the nose or mouth. If you get this medication in your eyes, nose, or mouth, rinse immediately with plenty of water.
COA:
Items of analysis |
Specification |
Results |
Description |
white or off-white crystalline powder |
white crystalline powder |
Identification |
A:uv B:HPLC |
complies |
Melting point |
265°C ~275°C |
265°C ~270°C |
Solubility |
water: practically insoluble / ethanol: slightly soluble |
complies |
Specificoptical rotation: |
+103°~+ 111° |
+ 106° |
Loss on drying |
≤ 0.5% |
0.13% |
Sulfated ash |
≤0.1% |
0.02% |
Heavy metal |
≤20ppm |
complies |
max impurity |
≤1.0% |
0.66% |
total impurities |
≤2.0% |
1.6% |
Assay(HPLC) |
97.0%~103.0% |
99.2% |
Dichloromethane |
not more than 600ppm |
complies |
Methanol |
not more than 3000ppm |
complies |
Pyridine |
not more than 200ppm |
complies |
Particle size |
99% ≤ 30 microns |
complies |
Conclusion |
Qualified |
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