CAS 50-55-5 Pharmaceutical Raw Materials Reserpine For Lower Blood Pressure
Superiority
Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
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Product Details:
Product Name |
Reserpine |
Synonyms |
|
reserpine crystalline; 3,4,5-Trimethoxybenzoyl methyl reserpate; Reserpine,98%; Reserpine base; Resperine; (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-16-(methoxycarbonyl)-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-4-ium;(3beta,16beta,17alpha,18alpha,20alpha)-11,17-dimethoxy-16-(methoxycarbonyl)-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-4-ium |
Molecular formula |
C33H40N2O9 |
Molecular weight |
608.68 |
EINECS |
200-047-9 |
Appearance |
off-white crystalline powder |
CAS |
50-55-5 |
MP |
~265 °C (dec.) |
Refractive index |
177 ° (C=1, DMF) |
Storage temp |
2-8°C |
Stability |
Stable, but darkens slowly in light. Combustible. Incompatible with strong acids, reducing agents, oxidizing agents. |
Usage |
An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive. |
Description:
Reserpine is an indole alkaloid, antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance.
Puhopharma specializes in controling the quality and reducing the impurities of Reserpine. Our Reserpine is with the best quality and the most competitive price in China. Reserpine derived from the roots of certain species of the tropical plant Rauwolfia.The powdered whole root of the Indian shrub Rauwolfia serpentina historically had been used to treat snakebites, insomnia, hypertension (high blood pressure), and insanity. Reserpine, isolated in 1952, was the first of many Rauwolfia alkaloids found in the crude drug. Because the drug produces a profound and prolonged tranquilizing action, it was once used in treating schizophrenia. Reserpine is sometimes used in treating hypertension, though newer antihypertensive drugs with fewer central nervous system side effects are the preferred treatment.
Application:
(1) Reserpine lowers blood pressure by slowing down your nervous system. This allows your blood vessels to relax and dilate (widen), which helps your heart beat more slowly and improves blood flow.
(2) Reserpine is used to treat hypertension (high blood pressure).
(3) Reserpine is also used to treat agitated psychotic conditions such as schizophrenia.
(4) Reserpine may also be used for purposes not listed in this medication guide.
Reserpine is one of the few antihypertensive medications that have been shown in randomized controlled trials to reduce mortality: The Hypertension Detection and Follow-up Program, the Veterans Administration Cooperative Study Group in Anti-hypertensive Agents, and the Systolic Hypertension in the Elderly Program. Reserpine is used with or without other medications to treat high blood pressure(hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It works by decreasing certain substances in the body (such as norepinephrine). This causes the blood vessels to relax so that blood can flow more easily and also slows the heart rate. These effects help to lower blood pressure. Reserpine is rarely used in the management of hypertension today. Reserpine is a second-line adjunct agent for patients who are uncontrolled on a diuretic when cost is an issue. It is also used to treat symptoms of dyskinesia in patients suffering from Huntington’s disease. In some countries reserpine is still available as part of combination drugs for the treatment of hypertension, in most cases they contain also a diuretic and/or a vasodilator like hydralazine. These combinations are currently regarded as second choice drugs.
COA:
Item |
Requirements |
Test Results |
Description |
white or yellow crystalline powder |
Yellow crystalline powder |
Specific rotation |
-115°~-131° |
-123.7° |
Identification |
(1)(2)(3)Positive reaction |
Positive reaction |
|
(4)Infrared absorption spectrum consistent with
the standard pattern |
Complies |
oxidation products |
Buy ultraviolet light (365 nm) examines may not show
obvious fluorescence |
No significant fluorescence |
Loss on drying |
≤0.5% |
0.20% |
Ignition residue |
≤0.15% |
0.04% |
Assay |
97.0%~103.0% |
99.70% |
Conclusion |
Meets the Requirements |
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