Medical Antipruritic Drugs Pramoxine HCl For Pain Killer
Product details:
| Product Name |
Pramoxine hydrochloride |
| Synonyms |
Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1);Pramoxine hydrochloride 4-n-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride;Pramoxine Hydrochloride (400 mg);4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride;gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride;p-butoxyphenylgamma-morpholinopropyletherhydrochloride;proctofoam;PRAMOXINE HCL |
| CAS No. |
637-58-1 |
| Molecular Formula |
C17H28ClNO3 |
| Molecular Weight |
329.86 |
| EINECS No. |
211-293-1 |
| Melting point |
181-183ºC |
| Boiling point |
427ºC at 760 mmHg |
| Flash point |
123.5ºC |
| Appearance |
White Powder |
| Purity |
99% |
| Quality Standard |
USP |
| Usage |
It relieves itching and pain in skin and anorectal diseases. |
Pramoxine Hydrochloride Fuction:
Structurally, it is the esther hydrochloride of p-n butoxyphenyl gammamorpholinopropane. The substance stood out as a good topical local anesthetic agent when Abbott Laboratories were researching a series of alkoxy aryl alkamine ethers for such an application. Pramocaine is tolerable by most mucus membranes and ranks low on the sensitizing index, making it unlikely to trigger an allergic reaction.
Surgical anesthesia:Epidural anesthesia (including epidural anesthesia during cesarean section);Local infiltration anesthesia.
Pramoxine Hydrochloride Description
Pramoxine Hydrochloride is a topical anesthetic and used as an antipruritic too. Chemical name is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research, Pramoxine Hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially great topical local anesthetic agent. Pharmacologic study revealed Pramoxine Hydrochloride to be very potent and of low acute toxicity, well tolerated by most mucous membranes and of a low sensitizing index. Pramoxine Hydrochloride reduces the permeability of neuronal membranes to sodium ions, blocking initiation and conduction of nerve impulse. Depolarization and repolarization of excitable neural membranes is thus inhibited by Pramoxine Hydrochloride, leading to the numb sensation.
The high potency and low acute and sub-acute toxicity of Pramocaine have popularized its usage in over-the-counter itching creams and sunburn lotions. It may also be used in treating rectal irritations. The drug is sometimes administered in a spray or wipe form.
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