Female Steroids Good Effect Legal Raw Material Pregnenolone Powder for Ending Pregency
Product descroption:
| Product Name |
Pregnenolone |
| CAS No |
145-13-1 |
| Assay |
99% |
| Molecular Formula |
C21H32O2 |
| Molecular Weight |
316.48 |
| EINECS |
205-647-4 |
| Quality Standard |
Enterprise Standard |
| Packing |
1kg/foil bag |
| Appearance |
White or almost white crystalline powder |
Description
Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.
Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.
Pregnenolone undergoes further steroid metabolism in one of three ways.
Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in production of 17-hydroxy progesterone and andros tenedione, precursor to test osterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandros terone (DH EA) using a desmolase. DH EA is the precursor of andros tenedione.
Pregnenolone can be converted to androsta-5,16-dien-3 beta-ol by 16-ene synthetase.
Application:
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus.
1.Used in the synthesis of steroid drug intermediate and steroid drugs;
2.Used as intermediate for the synthesis of progesterone, antiflamison;
3.With the same function of corticosteroids anti-inflammatory.
Package:25kg/drum, inner package two plastic bags
Storage:Stored in cool and dry place.Keep away from light and heat.
Shelf life:3 years if properly packaged.
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